AAIR: Antibody Antigen Information Resource

Antibody molecules and the antigen-antibody interaction

The immune system is a diffuse organ dispersed in the body and basically constitutes lymphoid cells, cytokine and antibody molecules. The latter are the product of lymphoid cells. In the past, the cellular basis for antibody formation was the subject of several theories, e.g., the selective theory according to P EHRLICH (1900), the instructive antigen-template theories as suggested by L PAULING...

Antigen-Antibody Immune Complexes

Studies on Antigen-antibody Complexes

Solid phase immunoadsorbents were prepared by coupling antigens to agarose. With this technique specific antibodies were easily isolated in large amounts. The gammaG-globulin class of antibodies isolated in this manner were not denatured as judged by their normal biological half-life in rabbits. Soluble immune complexes at fivefold antigen excess were prepared from isolated specific antibodies ...

Antigen Recognition and Antibody Specificity

The exact specifiicity of anti-DNP antibody produced by Hartley guinea pigs immunized with a series of defined alpha,DNP and epsilon,DNP-oligolysines was studied by fluorescence quenching. All responder animals made anti-DNP antibody which recognized the precise chain length, +/- 1 lysyl residue, of the DNP-oligolysines used to induce the immune response as measured by an increase in binding en...

Antigen arrays for antibody profiling.

Antigen array technologies enable large-scale profiling of the specificity of antibody responses against autoantigens, tumor antigens and microbial antigens. Antibody profiling will provide insights into pathogenesis, and will enable development of novel tests for diagnosis and guiding therapy in the clinic. Recent advances in the field include development of antigen array-based approaches to e...